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植物DNA双链断裂损伤修复机制研究进展 被引量：4

Advances in Repair Mechanism of DNA Double-strand Break Damage in Plant
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摘要 DNA双链断裂(DSBs)是细胞最严重的损伤形式之一。高等动植物中主要通过非同源末端连接(NHEJ)途径进行DNA双链断裂修复。该途径不依赖DNA同源性,由一些修复因子如:Ku蛋白异二聚体、DNA-PKcs、XRCC4和ligaseⅣ等,将断裂末端直接连接进行修复。综述了植物DNA双链断裂损伤修复的主要途径及其相关基因研究的进展,探讨了植物DNA损伤修复研究中存在的问题与发展方向。 The DNA double-strand breaks（DSBs） is one of the most serious form of DNA damage.Non-homologous end-joining（NHEJ） is the major pathway to repair DNA double-strand break damages in both higher plants and animals.The NHEJ pathway does not rely on DNA homology,while the number of such repair factors as Ku protein heterodimer,DNA-PKcs,XRCC4 and ligaseⅣ,will be directly joined the end to repair.The research progresses in major repair pathway and key genes involving in DNA double-strand break damages in plant are summarized.The existing problems and perspectives in this field are also discussed.
作者 朱彩霞 古佳玉 邵群 王晶 刘录祥
机构地区 中国农业科学院作物科学研究所 山东师范大学生命科学学院
出处 《中国农业科技导报》 CAS CSCD 2010年第5期17-23,共7页 Journal of Agricultural Science and Technology
基金 国家863计划项目(2007AA100102) “十一五”国家科技支撑计划项目(2008BAD97B01,2009BAA24B05) 农业部农业公益性行业科研专项(200803034) 国际原子能机构项目(CRP15651CPR5017)资助
关键词 DNA双链断裂 损伤修复 非同源末端连接 KU蛋白 XRCC4 DNA double-strand breaks damage and repair NHEJ Ku protein XRCC4
分类号 Q754 [生物学—分子生物学]
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参考文献50

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二级参考文献19

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共引文献4

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二级引证文献23

中国农业科技导报
2010年 第5期

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