奥美拉唑治疗消化性溃疡的剂量与疗程分析

Omeprazole dose and treatment of peptic ulcer

目的分析研究奥美拉唑对消化性溃疡的治疗剂量与疗程和疗效。方法将90例消化性溃疡患者随机分为两组,A组45例,用奥美拉唑20mg/d,治疗十二指肠溃疡4周,胃溃疡6周;B组45例用奥美拉唑40mg/d,治疗十二指肠溃疡2周,胃溃疡3周;两组患者均同时服用甲硝唑400mg,克拉霉素250mg,均2次/d。结果十二指肠溃疡的愈合率两组分别为84%和84%,胃溃疡的愈合率两组分别为85%和85%;十二指肠溃疡的总有效率两组分别为96%和96%,胃溃疡的总有效率两组均为100%,在愈合率与总有效率方面无明显差异。说明用奥美拉唑20mg/d,治疗时间要长,用奥美拉唑40mg/d,治疗时间则短,无论采取哪种方法,该药对消化性溃疡的治疗效果都是令人满意的。结论奥关拉唑对消化性溃疡的治疗效果是显著的,该药是质子泵抑制剂,能很好地抗胃酸分泌,迅速缓解症状,促进消化性溃疡的愈合。

Objective To analysis of peptic ulcer treatment omeprazole and efficacy of dose and duration.Methods90 cases of peptic ulcer patients were randomly divided into two groups,A group of 45 patients,omeprazole 20 mg /d,4 weeks of treatment of duodenal ulcer,gastric ulcer 6 weeks;B group of 45 patients with O＇Meara yl 40 mg /d,2 weeks treatment of duodenal ulcer,gastric ulcer 3 weeks;two groups of patients were also taking metronidazole 400 mg,clarithromycin 250 mg,both 2 times a day.ResultsTwo groups of duodenal ulcer healing rates were 84% and 84%,gastric ulcer healing rates of the two groups were 83.4 and 81.2%;the total effective rate of duodenal ulcer two groups were 96% and 96%,total effective rate of gastric ulcer groups were 100% in the healing rate and the total efficiency was no significant difference.Help with omeprazole 20 mg/d,longer treatment time,with omeprazole 40 mg/d,treatment time is short,regardless of which method to take the drug on the treatment of peptic ulcer were very satisfied.ConclusionNo matter which method above,Austria-yl pull off on the treatment of peptic ulcer is significant,omeprazole 20 mg /d,longer treatment time,with omeprazole 40 mg /d,treatment time is short,the drug is a proton pump inhibitor,can be a good anti-gastric acid secretion,rapidly relieve symptoms,promote healing of peptic ulcer.