基于ATP-结合盒转运蛋白逆转肿瘤多药耐药的研究进展

Advances in the targeting ATP-binding cassette transporters to overcome tumor multi-drug resistance

ATP-结合盒(ATP-binding cassette,ABC)转运蛋白是ATP依赖性药物外排泵,其表达或功能异常是肿瘤细胞产生多药耐药(multi-drug resistance,MDR)的重要机制之一。目前,以ABC转运蛋白为靶点的逆转肿瘤MDR的研究最为广泛与深入。本文总结了ABC转运蛋白的结构与功能、ABC转运蛋白与肿瘤MDR的关系及以其为靶点的MDR逆转剂与逆转策略的研究进展。

ATP-binding cassette （ABC） transporters are a family of proteins that mediate multi-drug resistance （MDR） via ATP-dependent drug efflux pumps. Abnormally expression and function would result in tumor MDR. That is the most important mechanism of MDR. The inhibition of ABC transporters as a strategy to reverse MDR in cancer has been studied extensively. In this review, we reviewed the structure and function of ABC transporters, and focused on the research advances in the mechanism of tumors MDR mediated by ABC transporters and the development of their modulators and reversal strategies.