妊娠期分化型甲状腺癌诊治分析

Analysis of well-differentiated thyroid carcinoma detected during pregnancy

目的:探讨妊娠期分化型甲状腺癌诊治方法。方法:回顾分析1988年6月-2009年10月我院20例妊娠期分化型甲状腺癌患者资料,根据手术时机分为A组(n=11):产后手术,B组(n=9):妊娠中期手术。结果:两组年龄、诊断时间、肿瘤分期、肿瘤大小、包膜浸润及淋巴结转移情况无明显差异,两组手术花费时间、手术方式及并发症、住院时间、术后局部复发及远处转移无显著差异。结论:妊娠期分化型甲状腺癌治疗效果良好,产后手术并不影响预后。

Objective：To investigate therapy of well-differentiated thyroid carcinoma during pregnancy.Methods： We retrospectively analyzed 20 cases of well-differentiated thyroid carcinoma detected during pregnancy between June 1988 and October 2009.The patients were divided into two groups according to the time of surgery.Group I（n=11）had thyroidectomy after delivery,Group II（n=9） had thyroidectomy during the second or third trimester.Results： No significant differences were noted between Groups I and II with regard to patient age,the timing of diagnosis,tumor size,TNM stage,and state of lymph node metastasis.There were no TNM stage changes in Group I,although there was a slight increase in tumor size during pregnancy in this group.Surgical outcome,with regard to type of operation,operation time,perioperative complications,length of hospital stay,and treatment outcome,did not differ significantly between 2 groups.Conclusion： In most patients,results of surgery on well-differentiated thyroid carcinoma detected during pregnancy is well and surgery after delivery can not affect the prognosis.