来曲唑联合唑来膦酸治疗绝经后乳腺癌骨转移疗效观察

Curative effect of letrozole combined with zoledronic acid in the treatment of postmenopausal breast cancer patients with bone metastasis

目的:观察来曲唑联合唑来膦酸治疗绝经后乳腺癌骨转移的临床效果及不良反应。方法:42例绝经后乳腺癌骨转移患者给予来曲唑片口服2.5mg/d,唑来膦酸4mg加入生理盐水100m l静滴,每4周1周期,两药连用3个周期后评价疗效。结果:治疗后止痛、体力状况的改善及骨转移病灶的有效率分别为85.71%、69.05%、45.24%,主要不良反应为发热。结论:来曲唑联合唑来膦酸治疗绝经后乳腺癌骨转移有较好的疗效,不良反应少,患者容易接受。

Objective：To observe the clinical curative effect and adverse reaction of letrozole combined with zoledronic acid in the treatment of postmenopausal breast cancer patients with bone metastases.Methods： We gave 42 patients with bone metastasis of postmenopausal breast cancer oral administration of letrozole tablets 2.5mg/d and intravenous infusion of ibandroante 4mg add 100ml saline water,every 4 weeks as a circle and evaluated the curative effect after three circles treatment.Results： After the treatment,the relief rates of pain,improvement of daily living activity and bone metastasis control rate were 85.71%,69.05%,45.24% respectively.The main adverse reaction was fever.Conclusion： Treatment on postmenopausal of breast cancer patients with bone metastasis by letrozole combined with zoledronic acid is effective and accepted by patients.