Fractalkine在糜烂-萎缩型及斑纹型OLP中表达的初步研究

Fractalkine expression in erosive-atrophic/reticular form of Oral Lichen Planus:a preliminary study

目的:探讨fractalkine(FKN)在OLP中的表达及意义。方法:采用免疫组织化学方法,检测FKN在34例OLP中表达情况,分析FKN阳性着色与OLP临床类型、年龄、性别及发病部位的关系。结果:FKN在OLP角质形成细胞中高表达,FKN阳性细胞率为(45.4±16.2)%;在糜烂-萎缩型OLP中,角质形成细胞FKN染色分值(2.8±0.7)较斑纹型OLP染色分值(1.9±0.8)高,有显著性差异(P<0.05)。OLP黏膜下层血管内皮细胞也发现FKN高表达。结论:FKN在角质形成细胞及血管内皮细胞中的高表达,可与T淋巴细胞相互作用,可能通过一种旁分泌反馈机制参与OLP发病机制,加重炎症反应。

Objective：In this study,we set out to investigate the expression of fractalkine（FKN）in oral lichen planus （OLP）.Method：FKN expression in OLP was evaluated by immunohistochemistry,and relationship with clinical form,age,gender and lesion site was also analyzed.Result：There was high expression of FKN in keratinocytes of OLP.The percentage of FKN positive in all keratinocytes was 45.4±16.2 % in 34 cases of OLP.The FKN positive score was significantly higher in erosive-atrophic form （2.8±0.7）than in reticular form （1.9±0.8）of OLP.FKN expression was also found in endoepithelial cells of small vessels in submucosa area.Conclusion：Expression of FKN in keratinocytes and endoepithelial cells may interact with T lymphocytes,then participate pathogenesis of OLP through a paracrine-feedback loop system.