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甲基化在癌前病变中的研究进展

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摘要 癌前病变具有一定的癌变潜能。DNA甲基化参与肿瘤的发生并在癌前病变中可以检测到,具有作为癌症早期诊断的分子标记物及治疗靶点的潜在价值。了解癌前病变中基因甲基化研究进展有助于癌症的早期发现和早期治疗。
作者 柳杨 周曾同 蒋伟文
机构地区 上海交通大学医学院附属第九人民医院.口腔医学院口腔黏膜科上海市口腔医学研究所.上海市口腔医学重点实验室
出处 《临床口腔医学杂志》 2010年第7期436-438,共3页 Journal of Clinical Stomatology
基金 国家自然科学基金资助项目(30872887) 上海市科学技术委员会资助项目(08DZ2271100) 上海市重点学科建设资助项目(S30206)
关键词 DNA 甲基化 表观遗传 癌前病变 口腔白斑
分类号 R780.2 [医药卫生—口腔医学] R781.5 [医药卫生—口腔医学]
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参考文献19

  • 1Mao L,Hong WK,Papadimitrakopoulou VA.Focus on head and neck cancer[J].Cancer Cell,2004,5(4):311-316.
  • 2Warnakulasuriya S,Reibel J,Bouquot J,et al.Oral epithelial dysplasia classification systems:predictive value,utility,weaknesses and scope for improvement[J].J Oral Pathol Med,2008,37(3):127-133.
  • 3Lumerman H,Freedman P,Kerpel S.Oral epithelial dysplasia and the development of invasive squamous cell carcinoma[J].Oral Surg Oral Med Oral Pathol Oral Radiol Ended,1995,79(3):321-329.
  • 4Silverman S Jr,Gorsky M,Lozada F.Oral leukoplakla and malignant transformation a follow-up study of 257 patients[J].Cancer,1984,53(3):563-568.
  • 5Kresty LA,Mallery SR,Knobloch TJ,et al.Alterations of p16INK4a and p14ARF in patients with severe oral epithelial dysplasia[J].Cancer Res,2002,62(18):5295-5300.
  • 6Takeshima M,Saitoh M,Kusano K,et al.High frequency of hypermethylation of p14,p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka[J].J Oral Pathol Med,2008,37(8):475-479.
  • 7刘宏伟,胡碧琼,曹采方.口腔白斑和鳞癌中p16基因甲基化的研究[J].中华口腔医学杂志,2005,40(2):94-97. 被引量：10
  • 8Cao J,Zhou J,Gao Y,et al.Methylation of p16 Cpg island associated with malignant progression of oral epithelial dysplasia:A prospective cohort study[J].Clin Cancer Res,2009,15(16):5178-5183.
  • 9M López,J M Aguirre,N Cuevasa,et al.Gene promoter hypermethylation in oral rinses of leukoplakia patients-a diagnostic and/or prognostic tool[J].Eur J Cancer,2003,39(16):2306-2309.
  • 10万扬,高文信,陈英新,崔玉波,刘永茂.口腔粘膜癌前病变及鳞癌中RASSF1A基因甲基化与表达的研究[J].现代口腔医学杂志,2007,21(1):30-33. 被引量：3

二级参考文献24

  • 1To KF, Leung WK, Lee TL, et al. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. Int J Cancer, 2002, 102: 623-628.
  • 2Nakahara Y, Shintani S, Mihara M, et al. High frequency of homozygous deletion and methylation of p16 (INK4A) gene in oral squamous cell carcinomas. Cancer Lett, 2001, 163: 221-228.
  • 3Herman JG, Merlo A, Mao L, et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res,1995, 55: 4525-4530.
  • 4Gonzalez-Zulueta M, Bender CM, Yang AS, et al. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res, 1995, 55: 4531-4535.
  • 5Merlo A, Herman JG, Mao L, et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med, 1995, 1: 686-692.
  • 6Herman JG, Jen J, Merlo A, et al. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res, 1996, 56:722-727.
  • 7Zingg JM, Jones PA. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis, 1997, 18: 869-882.
  • 8Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A, 1994, 91: 9700-9704.
  • 9Kashiwabara K, Oyama T, Sano T, et al. Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers. Int J Cancer, 1998, 79: 215-220.
  • 10Lo KW, Cheung ST, Leung SF, et al. Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res, 1996, 56: 2721-2725.

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临床口腔医学杂志
2010年 第7期

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