EB病毒与胃癌关系的初步探讨

Preliminary study on EB virus and gastric cancer

目的探讨本地区胃癌与EB病毒的关系。方法用聚合酶链反应方法检测本地区经病理确诊的胃癌组织标本58例、萎缩性胃炎24例及胃溃疡28例,其中胃癌组为病例组,萎缩性胃炎及胃溃疡设为对照。结果胃癌组织中EB病毒阳性7例,阳性率13.5%,而对照组EB病毒阳性0例,两者差异有统计学意义;不同分化程度胃癌EB病毒DNA检测结果不同,差异有统计学意义。结论 EBV感染可能是本地区胃癌发生的一个重要环境因素;EB病毒可能与恶性程度高的胃癌有关。

Objective To investigate the relationship between Epstein-Barr virus（EBV） and gastric carcinoma in Ningxia district.Methods Polymerase chain reaction（PCR） was used to detect EBVDNA in 58 cases of gastric carcinoma,24 of atrophic gastritis and 28 of gastric ulcer.Atrophic gastritis and gastric ulcer are controls.Results EBV sequences were detected in 13.5%（7/52） cases of gastric carcinoma but in none of the controls.Statistical analysis showed that there was significant difference between them.EBVDNA for different differentiation of gastric cancer is different,the difference was statistically significant.Conclusions EB virus infection may play an important role in gastric cancer in Ningxia region.It may be related to a high degree of malignant gastric cancer.