扩张型心肌病患者高尿酸血症和血浆BNP水平的关系及意义

The relationship of plasma BNP and uric acid level in dilated cardiomyopathy patient

目的:探讨扩张型心肌病患者高尿酸血症和血浆BNP水平的关系及意义。方法:采用化学发光法测定41例扩张型心肌病患者及30例健康对照者血浆BNP水平同时采用酶法测定其血尿酸水平。对扩张型心肌病患者按心功能恶化程度及血尿酸水平分组,对各组间血浆BNP水平进行统计学处理。结果:扩张型心肌病患者血浆BNP及血尿酸水平均显著高于对照组(P<0.01),且按心功能恶化程度逐级上升。高尿酸血症组的血浆BNP水平明显高于尿酸正常组(P<0.05)。结论:扩张型心肌病患者血浆BNP及血尿酸水平升高,且随着患者心功能分级的恶化而逐级升高,血浆BNP及尿酸水平可协同作为扩张型心肌病患者心功能分级及疗效评价的指标。

Objective：To explore the relationship of serum uric acid and plasma BNP level in dilated cardiomyopathy patients.Methods： The plasma BNP level was measured in 41 cases of dilated cardiomyopathy patients and 30 healthy people by chemiluminescene method.The serum uric acid level was measured by enzymatic method at the same time.The dilated cardiomyopathy patients were separated into groups according to the cardiac disfunction degree and serum uric acid level,and the plasma BNP level was analysed amony these groups by statistical methods.Results： The plasma BNP and serum uric acid level in dilated cardiomyopathy disease group were higher than healthy group significantly（P0.01）,and increasing with the degree of cardiac disfunction.The BNP level in hyperuricemia group was higher than control group（P0.05）.Conclusion： The plasma BNP and serum uric acid level increased in the dilated cardipmyopathy patients with the degree of cardiac disfuntion.They were good auxiliary indicators on cardic funtion classification and treatment effect estimation.