纤维蛋白原和血脂含量与冠状动脉病变的关系

Relation between serum fibrinogen with blood lipid and extent of coronary stenosis

目的:探讨纤维蛋白原(fibrinogen,FIB)与冠状动脉病变程度的相关性。方法:根据冠状动脉造影(coronary angiography,CAG)结果将326例疑诊冠状动脉粥样硬化性心脏病(简称冠心病)患者,根据狭窄血管支数分成单支、两支和三支组和对照组,术前检测血清FIB和血脂。比较FIB浓度在不同冠状动脉病变血管支数组间有无差异,FIB浓度与血脂进行相关分析并与冠脉病变血管支数进行多元逐步回归分析。结果:冠心病各组与对照组FIB浓度比较均有明显差异(P<0.05或0.01);FIB与HDL-C、ApoAI、TG、LDL-C、TC和ApoB明显相关(P<0.05);偏相关分析发现FIB浓度与冠状动脉病变血管支数明显相关(P<0.01)。结论:FIB浓度与冠状动脉病变的严重程度相关。

Objectives：To explore the relationship between serum fibrinogen（FIB） and the extent of coronary stenosis by using coronary angiography and measuring the serum fibrinogen （FIB）.Methods：326 patients suspected with CHD were selected in the cardiology department of our hospital from August,2006 to November,2009.After admission all candidates underwent coronary angiography and serum FIB was determined.According to the results of coronary angiography,all the patients were divided into 4 groups： normal control group （stenosis 50%）,single-vessel（LM or LAD or LCX or RCA） group,double-vessel group and triple-vessel group.The data were analyzed with multivariate regression.Results：（1）There was significant difference in the levels of FIB among these groups,except between single-vessel group and normal control group.（2）We found a linear correlation between FIB and TG,LDL-C,TC,HDL-C,ApoAI and ApoB.（3） The multivariate regression analysis showed that the serum FIB was correlated with the number of stenosis vessels.Conclusion： The level of FIB is related to the severity of the coronary artery lesion.