摘要
目的 探讨直肠癌浸润前沿区域CD97和配体CD55的表达与肿瘤复发转移及预后的关系.方法 用免疫组化方法检测71例直肠癌组织及30例正常结直肠组织CD97和CD55的表达情况.结果 直肠癌组织CD97、CD55表达水平显著高于正常肠黏膜组织,浸润前沿区域癌细胞CD97高表达患者肿瘤复发和/或转移率（67.8%）显著高于低表达患者（30.0%）,浸润前沿区域间质CD55高表达患者复发和/或转移率（64.5%）显著高于低表达患者（32.5%）（均P〈0.05）.浸润前沿区域癌细胞CD97表达与间质CD55表达呈正相关（r=0.392,P〈0.05）.单因素分析显示淋巴结转移、TNM Ⅱ～Ⅳ期、浸润前沿癌细胞CD97高表达为影响术后生存率的危险因素（均P〈0.05）.多因素分析显示淋巴结转移及浸润前沿癌细胞CD97高表达是影响直肠癌预后的独立危险因素（均P〈0.05）.结论 直肠癌浸润前沿区域CD97及其配体CD55表达水平与肿瘤复发转移以及预后密切相关.
Objective To investigate the expression of CD97 and its ligand CD55 at the invasion front of rectal carcinoma and its association with the disease prognosis. Methods The expression of CD97 and CD55 was immunohistologically detected in 71 tissue specimens of rectal carcinomas and 30 specimens of normal rectal tissue. Results The expression of CD97 and CD55 in rectal tumor tissues were significantly higher than that in normal rectal tissues （both, P〈0.05）. And the recurrence and/or metastasis rate （67.8%） in patients with high CD97 expression at the invasion front was significantly higher than that （30.0%） in patients with lower expression （P〈0.05）. The recurrence and/or metastasis rate （64.5%） in patients with high CD55 expression at the invasion front was higher than that （32.5%） in patients with lower CD55 expression （P〈0.05）. The expression of CD97 at tumor cells of invasion front was correlated with that of CD55 in the stroma at invasion front （r=0.392, P〈0.05）. Univariate analysis indicated that lymph node metastasis, stage Ⅱ～Ⅳ and high CD97 expression at the invasion front were risk factors for postopera- tive survival rate （P〈0.05）; multivariate analysis showed that only lymph node metastasis and high CD97 expression at the inva- sion front had statistical significance （P〈0.05）. Conclusion The expressions of CD97 and its ligand CD55 at the invasion front of rectal carcinoma are related to the recurrence, metastasis, and poor prognosis of rectal carcinomas.
出处
《浙江医学》
CAS
2010年第9期1311-1314,1317,共5页
Zhejiang Medical Journal
