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PTEN、PI3K、Survivin在非小细胞肺癌中的表达及相关性 被引量：7

Correlation of PTEN,PI3K and survivin expression in non-small cell lung cancer
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摘要 目的检测PTEN、PI3K和Survivin蛋白在非小细胞肺癌(NSCLC)组织中的表达,并对其表达水平与NSCLC临床特征之间的关系进行相关性分析,探讨其与NSCLC的浸润、转移和预后的关系。方法免疫组织化学SP法检测60例NSCLC组织、19例正常肺组织中PTEN、PI3K和Surivin蛋白的表达水平,运用单因素(Log-rank)和多因素(Cox比例风险模型)生存分析比较三者与各临床特征及预后之间的关系。结果 PI3K和Survivin在NSCLC中的阳性表达率显著高于正常肺组织(P<0.05),PTEN在NSCLC中的阳性表达率显著低于正常肺组织(P<0.05);PTEN与PI3K、Survivin蛋白表达呈负相关;PTEN阴性组的总生存时间显著低于阳性组,而Survivin和PI3K阳性组的总生存时间低于阴性组(P<0.05);临床TNM分期、PTEN、PI3K及Survivin表达是影响NSCLC患者预后的独立因素。结论 PI3K和Survivin在NSCLC中的表达上调,PTEN在NSCLC中表达下调,PTEN与PI3K、Survivin蛋白表达呈负相关,三者均为NSCLC预后的独立因素,监测它们的表达对评估NSCLC患者的预后具有一定的价值。 Objective To observe expressions of PTEN,PI3K and survivin in human non-small cell lung cancer（NSCLC） and investigate their correlations to the prognosis of NSCLC.Methods The expressions of PTEN,PI3K and survivin were detected in 60 NSCLC specimens using immunohistochemistry with SP method.Univariate and multivariate survival analysis were used to analyze the correlations of PTEN,PI3K and surivin to the clinic pathologic profiles and prognosis of NSCLC.Results Compared to normal lung tissues,there was up-regulation of positive rates for PI3K and survivin expression in NSCLC tissues（P〈0.05）,as well as down-regulation of PTEN expression（P〈0.05）.PTEN expression was negatively correlated with PI3K and survivin expressions.Patients with positive expression of PTEN had a longer survival time than PTEN negative patients,while patients with negative expression of PI3K and survivin showed a better prognosis than PI3K and survivin positive patients.Multivariate survival analysis identified that clinical TNM stages,expressions of PTEN,PI3K and survivin were independent prognosis factors of NSCLC patients.Conclusion The expression levels of PI3K and survivin are up-regulation and the expression level of PTEN is down-regulation,all of which are independent prognostic predictors of NSCLC.PTEN expression is negatively correlated with PI3K and survivin expressions.To detect their expressions may be valuable in evaluating the prognosis of NSCLC.
作者 张久荣 殷咏梅 刘连科
机构地区 南京医科大学第一附属医院肿瘤科 南京市胸科医院呼吸科
出处 《临床肿瘤学杂志》 CAS 2010年第9期789-793,共5页 Chinese Clinical Oncology
关键词 非小细胞肺癌 PTEN PI3K SURVIVIN 免疫组织化学 Non-small cell lung cancer PTEN PI3K Survivin Immunohistochemistry
分类号 R734.2 [医药卫生—肿瘤]
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参考文献13

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二级参考文献24

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临床肿瘤学杂志
2010年 第9期

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