食物特异性IgG抗体检测在过敏性紫癜中的应用分析

Application of Serum Food-specific IgG Detection in Patients with Henoch-schonlein Purpura

目的 探讨食物不耐受与过敏性紫癜的相关性.方法 采用ELISA方法检测63例过敏性紫癜患者血清中14种食物特异性IgG抗体.结果 63例过敏性紫癜患者中有44例检测到1～12种食物特异性IgG阳性升高,总阳性率为69.8%（44/63）;特异性IgG阳性率在10%以上的主要致敏食物有5种,阳性率由高至低分别为牛奶（34.9%）,鸡蛋（30.2%）,小麦（23.8%）,螃蟹（11.1%）,大豆（11.1%）;食物特异性IgG浓度分级结果表明,多数食物以引起轻度不耐受（即IgG浓度为＋1级）的病例为主;患者食物不耐受检出阳性率以及14种食物IgG阳性率在不同性别间差异均无统计学显著性意义（P〉0.05）;食物不耐受阳性患者中,对1～2种食物不耐受者所占比例较多（分别为45.4%和36.4%）.结论 过敏性紫癜患者食物不耐受发生率较高,食物不耐受与过敏性紫癜具有密切相关性.食物特异性IgG抗体检测对过敏性紫癜防治将具有重要意义.

Objective To explore the relationship between food intolerance and Henoch-schonlein Purpura. Methods A total of 63 patients with Henoch-schonlein Purpura were enrolled in this study. 14 food-specific IgG antibodies in serum of these patients were detected by ELISA assay. Results Food-specific IgG antibodies were positive in the serum of 44 cases and the total positive rate was 69.5%. The positive rates of 5 kinds of food,listed from high to low,were milk（34.9%）, egg （30.2%）, wheat （23.8%）, crab （ 11.1%）, soybean （ 11.1%）, respectively. There was not significantly difference between the positive rate of male and female（P^0.05）. Conclusion A high positive rate of food intolerance was found in patients with Henoch-schonlein Purpura. There was a close relationship between food intolerance and Henoch-schonlein Purpura. Detection of food-speclfic IgG antibody in serum of patients was of importance for diagnosis, treatment and prevention in Henoch-schonlein Purpura.