血液TNF-α和乳酸检测在新生儿缺氧缺血性脑病中的临床意义

Clinical Significance of TNF-α and Lactate Levels in the Newborns with Hypoxic-ischemic Encephalopathy

目的 探讨新生儿缺氧缺血性脑病（hypoxic-ischemic encephalo-pathy,HIE）患儿血液中肿瘤坏死因子-α（TNF-α）和乳酸（LAC）的变化及其临床意义.方法 将62例缺氧缺血性脑病新生儿分为轻、中、重三组,分别检测患儿血液中TNF-α和LAC的水平,并与30例健康新生儿比较.结果 HIE组血液中TNF-α和LAC的水平明显升高,与健康新生儿比较差异有统计学意义（P〈0.01）;随着病情的发展,TNF-α和LAC的水平升高越明显;恢复期TNF-α和LAC的水平则明显下降,与正常对照比较,差异无统计学意义（P〉0.05）.结论 血液中TNF-α,LAC参与了HIE的发生发展过程,可作为HIE的警示参数及诊断指标,对预测患儿病情变化和判断预后具有一定的指导意义.

Objective To explore the change of tumor necrosis factor-α（TNF-α） and lactate（LAC） in the newborns with hypoxic-ischemic encephalo-pathy（HIE）.Methods 62 patients were divided into three groups, group A（n=31）,B（n= 20） and C（n=11）. 30 healthy subjects were served as control group. Plasma TNF-α and LAC levels were detected simultaneously. Results The TNF-α and LAC levels in the newborns with HIE increased sharply and significant differences were observed as compared with controls（P〈0, 01）. And in convalescence stage, the levels of TNF-α and LAC in HIE decreased significantly（P〉0.05）. Conclusion TNF-α and LAC are related to the occurrence and development of HIE. They could be regarded as alarm sterms or dignosis standard of HIE,and be used to evaluate the porgnosis.