具体性自传体记忆任务下抑郁症患者的功能磁共振成像特点

Characteristics of functional magnetic resonance image in activated brain areas under specific autobiographical memory in patients with depression

目的探讨青年抑郁症患者在具体性自传体记忆任务下的功能磁共振成像(fMRI)特点。方法利用西门子1.5T功能性磁共振成像系统,检测12例抑郁症患者和12名健康志愿者在具体性自传体记忆任务下的大脑激活情况。采用国际通用的SPM5软件在MATLAB2007a上对两组被试的功能性磁共振原始图像数据进行预处理,再进行两样本t检验。结果与正常对照组相比,抑郁症患者在具体性自传体记忆任务下激活程度减弱(P<0.01)的脑区包括左侧颞中回(BA21)、壳核、右侧梭状回(BA37)和枕叶楔叶(BA18),而激活程度增强(P<0.01)的脑区为右侧顶叶上回(BA7)。结论抑郁症患者在具体性自传体记忆任务下的大脑激活模式与正常个体存在明显差异,抑郁症患者可能存在提取具体性记忆事件的相关脑区功能受损。

Objective To study the characteristics of functional magnetic resonance image（fMRI） in activated brain areas under specific autobiographical memory in young patients with depression.Methods 1.5T Simens Sonata MRI system was used to show the characteristics of fMRI in activated brain areas of 12 depression patients and 12 matched healthy volunteers under specific autobiographical memory task.fMRI data were processed using the SPM5 software.Two samples were analyzed by student＇s t test.Results The activation was weaker in left middle temporal gyrus（BA 21）,right fusiform gyrus（BA 37）,left cuneus（BA 18）,putamen,and stronger in the right superior parietal lobule（BA 7） in depression patients than in healthy controls（P 0.01）.Conclusion The activated brain areas are significantly different in depression patients and healthy controls under specific autobiographical memory task,indicating that the function of related brain areas in depression patients is impaired under specific memory events.