红果樫木化学成分研究

Chemical Constituents of Dysoxylum binectariferum

目的:研究红果樫木(Dysoxylum binectariferum)茎皮中的化学成分。方法:利用硅胶,反相RP18,凝胶LH-20等柱色谱及HPLC对红果樫木茎皮95%乙醇提取部分进行分离和纯化,用波谱方法鉴定其结构。结果:从红果樫木茎皮中分离得到5个化合物,包括3个倍半萜类化合物,鉴定的5个化合物分别为10β,15-Hydroxy-T-muurolol(1)、10β,15-Hydroxy-α-cadinol(2)、10α,15-Hydroxy-α-cadinol(3)、异莨菪亭(4)、3,4-二甲氧基苯甲醇(5)。结论:化合物1、2、4、5为首次从该属植物中分离得到。

Objective： To isolate the chemical constituents from the stem bark of Dysoxylum binectariferum and identify their structures.Methods： The powdered stem bark of D.binectariferum were extracted with 95% ethanol and purified by silica gel,RP-C18 and Sephadex LH-20 column chromatograph and HPLC.The chemical structures were elucidated on the basis of spectroscopic analysis.Results： Five compounds were isolated from the stem bark of D.binectariferum including three Sesquiterpenes.The five compounds were identified as 10β,15-Hydroxy-T-muurolol（1）,10β,15-Hydroxy-α-cadinol（2）,10α,15-Hydroxy-α-cadinol（3）,Isoscopoletin（4）,3,4-Dimethoxybenzyl alcohol（5）,respectively.Conclusion： Compounds 1,2,4,5 are isolated from the genus of Dysoxylum for the first time.