小剂量胺碘酮和贝那普利联合治疗阵发性房颤41例的临床观察

Observation of benazepril and low-dose amiodarone on patients with paroxysmal atrial fibrillation

目的:探讨小剂量胺碘酮与贝那普利联合治疗心功能正常的阵发性心房颤动(PAF)的临床疗效。方法:将41例PAF随机分为胺碘酮组(对照组21例)和胺碘酮加贝那普利组(治疗组20例),治疗随访时间为1年。观察2组窦性心律维持率和左心房内径变化。结果:2组治疗前后12个月间左心房内径差异显著(P<0.05);治疗后第2、4、6、8个月,对照组组窦性心律的维持率低于治疗组,但差异无统计学意义,治疗10、12个月后,2组间差异有统计学意义(P<0.05)。结论:胺碘酮与贝那普利联合治疗心功能正常的PAF维持窦性心律的疗效优于单用胺碘酮,贝那普利可以延缓左心房的扩大。

Objective：To evaluate the clinical efficacy of Benazepril combined with low-dose Amiodarone in patients with idiopathic paroxysmal atrial fibrillation（PAF）.Method：41 patients with paroxysmal atrial fibrillation（PAF）were divided into control group（Amiodarone group,n= 21）.and treatment group（Amiodarone plus benazepril n=20）randomly.Two groups had been followed up for one year.The sinus rhythm maintenance and left atrial diameter（LAD）were measured before and after treatment in the two groups.Result：The difference of LAD was significant（P0.05）between the two groups before and at the 12th month after treatment.The maintenance rate of sinus rhythm in control group was lower,but not significant,than that of treatment group at the 2th,4th,6th,8th month..However,there were significant differences at 10th,12th month（P0.05）after treatment.Conclusion：The combination of Benazepril and Amiodarone is more effective than Amiodarone alone for sinus rhythm maintenance..Angiotensin converting enzyme inhibitors may delay the enlargement of left atrium.