摘要
目的:探讨脓毒症患者中凝血异常的发生率和病情严重程度的关系。方法:分析了2009年3月-2009年8月在上海交通大学附属第一人民医院ICU和急诊病房住院符合脓毒症诊断标准的124例。分别在入院第1、7、14天测D-二聚体(D-dimer)、血小板计数、凝血全套。入院当天给以APACHEII评分、SOFA评分。根据D-dimer值分为3组,分别是D-dimmer<256μg/L、256≤D-dimer<1000μg/L、D-dimer≥1000μg/L。结果:所有入选病例第1、7、14天发生凝血异常的比例分别是38.7%、41.1%、45.9%。凝血异常组和无凝血异常组比较,D-dimer差异有统计学意义。随着D-dimer浓度增加,APACHEII和SOFA分值增加。结论:近半数脓毒症患者存在凝血功能障碍,其中D-dimer检测早期凝血功能障碍更为敏感。D-dimer与脓毒症的严重程度相关。
Objective:To investigate the relationship between prevalence of coagulation abnormalities and severity in sepsis.Method:124 sepsis patients in our ICU and emergency ward from Mar 2009 to Aug 2009 were divided into three groups according to various concentration of D-dimer.They were D-dimmer256 μg/L group,256≤D-dimer1000 μg/L group,D-dimer≥1 000 μg/L group.D-dimer,PLT and complete coagulation test on day1,day7 and day14 were measured.All the patients received APACHE II and SOFA tests at the 1st day.Result:The ratio of coagulation abnormalities at day1,day7 and day14 were 38.7%,41.1%,45.9%,respectively.D-dimmer increased significantly in coagulation abnormalities groups compared with that in non-coagulation abnormalities groups.With the increase of D-dimmer,the scores of SOFA and APACHE II were up-regulated.Conclusion:Nearly half of the sepsis patients had coagulation abnormalities.D-dimer was more sensitive to test early coagulation abnormalities and had a rational relationship with severity of sepsis.
出处
《临床急诊杂志》
CAS
2010年第4期232-233,236,共3页
Journal of Clinical Emergency
关键词
脓毒症
D-二聚体
凝血异常
sepsis
D-dimmer
coagulation abnormalities