滤过性手术中联合应用丝裂霉素C效果观察

FILTERING SURGERY WITH LOCAI APPLICATION OF MITOMYCIN C

目的：评价顽固性青光眼滤过性手术中联合应用丝裂霉素Ｃ（ＭＭＣ）的近期眼压和视功能结果。方法：５１例６１眼顽固性青光眼，全部采用小梁切除术，术中联合应用ＭＭＣ，ＭＭＣ浓度为０．２ｍｇ／ｍｌ～０．４ｍｇ／ｍｌ，局部接触时间２～５分钟。结果：随访３～１８个月，５５眼（９０．１６％）眼压在不用药物情况下＜２１ｍｍＨｇ，视功能未恶化。并发症：白内障形成或加重１０眼，浅前房４２眼，脉络膜脱离６眼，低眼压性黄斑病变４眼。结论：小梁切除术联合术中应用ＭＭＣ在顽固性青光眼患者获得了满意的近期眼压控制效果。

Objective:To evaluate short term outcome of filtering surgery with local application of mitomycin C for refractory glaucoma,intraocular pressure(IOP)and vision acting as evaluating indexes.Methods:Fifty one patients (61 eyes)with refractory glaucoma who underwent trabeculectomies with mitomycin C were reviewed.These operated eyes were followed up for 3～18 months,with an average of 11 months.The concentrations of mitomycin C varied from 0.2 to 0.4 mg/ml and local contact time from 2 to 5 minutes.Results:during the follow up period,IOP of 55 eyes(90.16%) was<21mmHg without administration of antiglaucoma drugs;their vision not deteriorated.Postoperative complications included cataract formation progression(n=10),shallow anterior chamber(n=42),choridal detachment(n=6) and hypotony (n=4);some of them were cured or restored to normal.Conclusion:The IOP reduction after filtering surgery with mitomycin C for refractory glaucoma is satisfactorily sustained during the short term followp up.