47例多发性骨髓瘤综合分析

Comprehensive analysis on multiple myeloma:a report of 47 cases

目的:探讨多发性骨髓瘤的临床特征及诊断措施。方法:对我院47例多发性骨髓瘤患者的临床一般资料、实验室检查进行回顾性分析。结果:IgG-κ轻链型占29.8%(14/47);IgG-λ轻链型占31.9%(15/47);IgA-κ轻链型占6.4%(3/47);IgA-λ轻链型占12.8%(6/47);IgM、IgD型各占2.1%(1/47);单纯κ轻链型占6.4%(3/47);单纯λ轻链型占6.4%(3/47);不分泌型占2.1%(1/47);κ/λ型之比为0.81/1。结论:多发性骨髓瘤临床表现多样,对可疑患者进行全面系统的检查,尤其是血清免疫固定电泳、免疫球蛋白测定、X线检查及多部位骨髓穿刺检查是确诊的重要手段,对早期诊断、判断分型以及指导治疗、提高患者生存期有重要意义。

Objective：To investigate the clinical characteristics and diagnosis measure of multiple myeloma （MM）. Method：Retrospective analysis was performed on the clinical and laboratory data of 47 MM patients.Result：In these 47 MM cases,there were 14 IgG kappa case （29.8%）,15 IgG Lambda （31.9%）,3 IgA kappa （6.4%）,6 IgA lambda （12.8%）,each 1 IgM and IgD （2.1%）,each 3 kappa and Lambda （6.4%） and 1 nonsecretion （2.1%）.κ/λ was 0.81/1.Conclusion：MM patients might have different symptoms. Doubtful patient should have systemic check,especially including immunofixation electrophoresis,immunoglobulin determination,X-ray and bone marrow aspiration,which would be important methods to define MM and play a crucal role in early diagnosis,typing,therapy and raising life span of MM.