血小板膜CD62P在冠脉介入治疗术后不同时期的表达

Platelet CD62P expression in different postoperative periods of PCI

目的:研究血小板膜CD62P表达率在冠状动脉介入治疗(PCI)术前和术后的变化。方法:检测60例急性心肌梗塞患者行PCI术前、术后即刻和术后7d的血小板膜CD62P表达率。结果:血小板膜CD62P表达率术前为(17.83±7.67)%、术后即刻降为(13.82±4.85)%,术后7d再降为(10.28±3.24)%,术前与术后即刻的CD62P表达率及术后即刻与术后7d的CD62P表达率均有显著差异(P均<0.05)。结论:PCI术后血小板膜CD62P表达率较术前明显下降,重建闭塞冠脉血运和抗血小板治疗能减轻心血管事件中的炎症反应。

Objective： To study the CD62P expression of platelets after PCI. Methods： The platelet CD62P expression of 60 cases of acute myocardial infarction undergoing percutaneous coronary intervention （PCI） treatment were detected before, immediately and 7 days after PCL Results： Preoperative platelet membrane CD62P expression rate was （17.83± 7.67） %. Platelet membrane CI）62P expression rate immediately decreased to （ 13.82 ± 4.85 ）% after PC1, and 7 days after PCI decreased to （10.28± 3.24）%. Preoperative and postoperative CD62P expression rate was significantly different （P〈0, 05）; it was also significantly different （P〈0.05） between immediately after and 7 days after PCI. Conclusion： PCI postoperative platelet CD62P expression rate significantly decreases compared with that of preoperative. Reconstruction of occluded coronary blood flow and anti-platelet therapy can reduce inflammatory response in cardiovascular events.