磷酸肌酸对早期舒张功能障碍的疗效(英文)

Therapeutic effect of creatine phosphate in early diastolic dysfunction

目的:探讨磷酸肌酸钠(CP,里尔统)治疗心肌早期舒张功能障碍的疗效。方法:心肌舒张功能障碍患者138例,分为磷酸肌酸钠组(109例)常规治疗组(29例),所有患者均进行常规治疗。磷酸肌酸组在常规治疗的基础上,给予CP2g+5%葡萄糖或0.9%的氯化钠100ml静脉滴注,轻度舒张功能减低者每天1次,中度舒张功能减退者每天2次,连续7～14d为1疗程。采用彩色多普勒超声心动图检测二尖瓣口舒张早期峰值流速(E)、二尖瓣口舒张晚期峰值流速(A),二尖瓣环舒张早期速度峰值(Ea)、二尖瓣环舒张晚期速度峰值(Aa),计算E/A比值,Ea/Aa比值和E/Ea比值,对比治疗前后两组临床症状、体征及彩色多普勒超声心动图各指标改善情况。结果:治疗后两组患者所有症状和体征均有明显的改善(P<0.05～0.01),且磷酸肌酸钠组临床显效率(96.2%)明显高于常规治疗组的57.1%(P<0.01)。磷酸肌酸钠组E/A比值(81.65%∶10.34%)、Ea/Aa比值(83.49%∶13.79%)、E/Ea比值(92.86%∶12.00%)的显效率均显著高于常规治疗组的(P均<0.01)。结论:磷酸肌酸钠对于改善心脏舒张功能和病情有显著疗效。

Objective：To investigate the therapeutic effect of c reatine phosphate sodium （CP, Neoton） at early stage of myocardi- um diastolic dysfunctior. Methods.. A total of 138 cases with myoeardium diastolic dysfunction were divided into CP group （n= 109） and routine treatment group （n=29）. All the patients received routine treatment. The CP group received CP treatment based on routine treatment（CP 2g＋ 5 % glucose or 0. 9 % sodium chloride 100ml, iv. drip, for patients with mild diastolic dys- function was ltime/d, patients with moderate diastolic dysfunction was 2 times/d）, duration was 7 -- 14 days. Color-coded Doppler echocardiography was used to detect transmitral peak early diastolic velocity （E-wave） ,transmitral peak late diastolic velocity （A-wave）, peak early diastolic velocity of mitral annulus （Ea）, and peak late diastolic velocity of mitral armulus（Aa）, and the value of E/A ,Ea/Aa and E/Ea were calculated. Symptoms, signs and items from echoeardiography were compared between the two groups before and after treatment. Results： After treatment, all symptoms and signs of patients in two groups significantly improved （P〈0. 05-0.01）, and the marked effective rate in CP group was significantly higher than that of routine treatment group （96.2% vs. 57.1%, P〈0.01）. In CP group, the marked effective rate of E/A （81.65% vs. 10. 34%）, Ea/Aa （83. 49% vs. 13.79%） and E/Ea （92. 86% vs. 12. 00%） were significantly higher than those in routine treatment group （P〈0.01all）. Conclusion： Creatine phosphate possesses marked effect for improving patient＇s condition and diastolic dysfunction.