硝酸酯对老年女性冠心病患者动脉弹性的影响

Effects of isosorbide mononitrate on arterial elastic function in elderly female patients with coronary artery disease

目的:评价单硝酸异山梨酯药物对老年女性冠心病患者动脉弹性的影响。方法:82例老年女性冠心病患者被随机分为硝酸酯组及常规治疗对照组(对照组),研究开始前及研究3个月后采用欧姆龙/科林动脉硬化诊断仪测定两组患者脉压、肱-踝脉搏波传导速度(baPWV),评价患者动脉弹性功能。结果:单硝酸异山梨酯组患者脉压明显低于对照组[(44.32±6.72)mmHg∶(56.21±11.23)mmHg,P<0.001],baPWV也明显低于对照组[(1938.67±361.92)m/s∶(2051.32±412.63)m/s,P<0.01]。结论:单硝酸异山梨酯有改善老年女性冠心病患者动脉弹性的作用。

Objective： To assess the effects of isosorbide mononitrate on arterial elastic function in elderly female patients with coronary artery disease （CAD）. Methods： A total of 82 elderly female CAD patients were randomly divided into isosorbide mononitrate group and routine therapy control group （control group）, pulse blood pressure and braehi- abankle pulse wave velocity （baPWV） were measured using a volume-plethysmographie apparatus （Omron Co. Ltd） at the beginning and the end of the 3--month period of study. Results： The pulse blood pressure was much reduced in isosorbidemononitrate group, compared with that of the control group [（44.32±6.72） mmHg vs. （56.21±11.23） mmHg, P〈 0. 001]. The baPWVs of isosorbide rnononitrate group also significant decreased compared that of control group [ （1938.67±361.92） m/s vs. （2051.32±412.63） m/s, P〈 0.01]. Conclusion： Theisosorbidemononitrate may improve arterial elastic function in elderly female patients with coronary artery disease.