食管癌术后纵隔转移灶常规分割联合立体定向放射治疗的疗效分析

Curative effect analysis of conventional fractionated radiotherapy conmbined with stereotactic radiotherapy for mediastinal metastasis from esophageal carcinoma postoperation

目的探讨胸段食管癌根治术后纵隔转移灶常规分割联合三维适形放射治疗的意义和效果。方法 89例食管癌术后纵隔淋巴结转移患者,接受常规分割照射40Gy/20Fx后行立体定向放射治疗,5.0Gy/次,5～6次,照射总剂量65～70Gy。评价近期疗效、毒副作用和生存率。结果治疗后1个月复查,病灶达CR41例,PR46例,SD2例,有效率97.8%(87/89)。1,2,3年生存率分别为75.0%,42.7%,18.0%%。主要毒副作用可以耐受。结论食管癌根治术后发生纵隔转移进行常规分割联合立体定向放射治疗可以明显提高局部控制率和生存率,毒副作用可以耐受。

Objective To evaluate the effect of conventional fractionated radiotherapy conmbined with stereotactic radiotherapy for mediastinal metastasis from postoperative esophageal carcinoma.Methods Eighty-nine patients were treated with conventional fractionated radiotherapy（40Gy/20Fx）combined with stereotactic radiotherapy（25Gy-30Gy/5-6Fx）.Short-term effect,acute adverse action and survival were evaluated.Results After one month,the CR,PR,SD were 41,46 and 2 cases,the overall response rate was 97.8%.the 1-year,2-year and 3-year survival rate were 75%,42.7% and 18.0%%.the adverse effect can be tolerated.Conclusion Conventional fractionated radiotherapy conmbined with stereotactic radiotherapy can enhance the local control rate and survival rate of mediastinal metastasis from postoperative esophageal carcinoma.