基于基因本体的语义相似度研究

Research on Semantic Similarity Based on Gene Ontology

针对基因本体的有向无环图结构,提出一种新的计算基因本体中术语间语义相似度的方法。该方法通过计算2个术语的公共祖先及符合条件的不相交祖先,得到不相交祖先的信息量平均值和2个术语的信息量平均值,并将2个平均值的比值作为2个术语的语义相似度。实验结果证明该方法准确度较高。

Basedon the directed acyclic graph structure of gene ontology,this paper proposes a novel method to measure the semantic similarity of gene ontology terms.By calculating the common ancestors of two terms and the disjunctive ancestors according with the condition,the average information content of disjunctive ancestors and the average information content of the two terms are obtained.The semantic similarity of two terms is the ratio of the average information content of disjunctive ancestors to the average information content of two terms.Experimental results show that the method has high accuracy.