肝硬化患者红细胞免疫功能的变化与血清脂联素水平的相关性分析

Relationship Between Perpheral Red Blood Cells Immunofunction Status and Serum Adiponectin Levels in Patients with Liver Cirrhosis

探讨了肝硬化患者外周血红细胞免疫功能的变化和血清脂联素水平的相关性,应用放射免疫分析法和免疫法对62例肝硬化患者进行了红细胞免疫功能和血清脂联素水平检测,并与35名正常健康人作比较。肝硬化患者红细胞C3b受体花环率(RBC-C3bRR)水平和血清脂联素水平明显降低(P<0.01),而红细胞免疫复合物受体花环率(RBC-ICRRR)水平明显升高(P<0.01),RBC-C3bRR水平与脂联素水平呈正相关(r=0.6132P<0.01),而RBC-ICRRR水平与血清脂联素水平呈明显负相关(r=-0.5988P<0.01)。肝硬化患者存在着免疫调节的紊乱,免疫功能低下与血清脂联素水平有一定的相关性。

To investigate the relationship between the changes of perpheral blood red blood cells immunofunction Status and Serum adiponectin levels in patients with Liver Cirrhosis.The RBC immumo-function status was studied with immunologic method and serum adiponectin Levels were measured with RIA in 62 patients with Liver Cirrhosis and 35 controls.The results showed that the levels of RBC-C3bRR and serum adiponectin were significantly lower and levels of RBC-ICRRR were significantly higher in the patients than those in controls（P0.01）.The RBC-C3bRR levels were positively correlated with serum levels of adiponectin（r=0.6132,P0.01）.The RBC-ICRRR levels were negatively correlated with serum levels of adiponectin（r=-0.5988 P0.01）.There is a turbulence of RBC-immuno-regulation with suppressed immunofunction in patients with liver cirrhosis.