膜缘柴胡与柴胡(北柴胡)抗炎、解热作用的比较

Comparation on the Effect of Autiinflammatory and Antipyretic between Bupleurum Chinese DC. and B. marginatum Wall. exDC

目的:常用中药柴胡临床使用时存在品种和入药部位的差异,本研究紧密结合柴胡的功效,选有柴胡主流品种以根入药的北柴胡与以地上部分入药的膜缘柴胡进行主要有关药效学的研究,进而明确两者解表退热功效的差异,以期为临床有效、合理使用柴胡提供指导。方法:采用二甲苯致小鼠耳廓肿胀,干酵母致大鼠发热模型,分别研究膜缘柴胡和北柴胡的抗炎、解热作用。结果:膜缘柴胡和北柴胡均可抑制二甲苯致小鼠耳廓肿胀,均可显著降低酵母致大鼠发热的温度。结论:膜缘柴胡、北柴胡都有良好的抗炎、解热作用,两者比较以北柴胡解热作用更强,因此两者能解表退热,其中北柴胡退热功效强于膜缘柴胡。

Objectives：Clinical use of the Bupleurum is different inspecies and medicines site,in order to use the Bupleurum more effective,reasonable,this paper choose the medicine with the Bupleurum Chinese DC.root and the shoot of B.marginatum Wall.ex DC.to research the different in Pharmacodynamic aspects,and to further clarified the different effect of releasing Exterior Syndrome and relieving fever.Method：Use xylene to make mouse ear edema,use dry yeast to make rats induced fever to research the different in pharmacodynamic aspects in anti-inflammatory,antipyretic effect between the B.marginatum Wall.ex DC.and Bupleurum chinese DC.Results：Both B.marginatum Wall.ex DC.and Bupleurum chinese DC.can inhibit xylene-induced mouse ear edema.Both B.marginatum Wall.ex DC.and Bupleurum chinese DC.can reduce the temperature of the yeast-induced fever significantly.Conclusions：The experimental study have shown that B.marginatum Wall.ex DC.and Bupleurum chinense DC.have good effective of anti-inflammatory and dissipated heat.Both B.marginatum Wall.ex DC.and Bupleurum chinense DC.have effect of releasing Exterior Syndrome and relieving fever.In the effect of relieving fever,Bupleurum chinense DC.is stronger than B.marginatum Wall.ex DC.