ACE基因多态对小儿激素敏感性肾病复发的影响

The Effect of Polymorphism of ACE Gene on the Relapse of Steroid Responsive Nephrotic Syndrome

目的：血管紧张素转换酶（ACE）基因多态性与多种肾脏疾病的发生和发展有关。本研究分析是否ACE基因多态性，独立或与PAF分解酶基因突变协同地，作用于激素敏感性肾病（SRNS）的发生发展。材料与方法：对象为SRNS患儿101例，以100例健康者为对照。应用PCR决定ACE基因多态（缺失DD、插入Ⅱ纯合型和ID杂合型），对所有患儿均行PAF分解酶基因型别（GG、GT和TT）分析。结果：同时有ACE基因缺乏型（ID/DD）和PAF分解酶基因突变（GT）者起病后第1年的复发次数显著增高，P＝0.01。结论：ACE基因多态性，通过与PAF分解酶基因突变的协同作用对SRNS的复发产生影响。

Objective: Angiotensin - converting enzyme (ACE) gene polymorphism has been reported to be involved in the pathogenesis of glomerulaonephritis. In this study, we evaluated weather ACE gene polymorphism is involved independently or synergistically with platelet - activating factor (PAF) acetylhydrolase gene mutation in steroid responsive nephrotic syndrome (SRNS) in children. Materials and Methords: 101 SRNS children and 100 healthy adults were studied. An insertion or deletion (I/D) polymorphisms of ACE genotypes were determined by PCR. The PAF acetylhydrolase genotypes were studied in the same patients. Results: Patients both having deletion genotype of ACE and the PAF acetylhydrolase gene mutation had significantly more relapses during the first year from onset (p = 0. 01 ). Conclusions: We have found that the ACE deletion gene polymorphism and PAF acetylhydrolase gene mutation have a synergistic effect on the relapse in SRNS children.