摘要
目的探讨病毒性心肌炎(VM)患者血清白介素-18(IL-18)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平的变化及临床意义。方法收集28例急性期和20例恢复期VM患者血清,采用酶联免疫吸附法(ELISA)测定IL-18、IL-6和TNF-α水平,采用免疫抑制法测定磷酸肌酸激酶同工酶(CK-MB),并与30名正常对照组进行比较。结果 VM急性期血清IL-18、IL-6、TNF-α及CK-MB水平显著高于恢复期及对照组(P<0.01),而恢复期与对照组比较差异均无显著性(P>0.05)。VM急性期IL-18、IL-6、TNF-α与CK-MB呈正相关(P<0.05)。结论 IL-18、IL-6、TNF-α的表达可能在VM发病过程中起重要作用,并可作为病情评估和预后判断的观察指标。
Objective To explore the changes of serum interleukin-18（IL-18）,interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） levels in the patients with viral myocarditis（VM） and their clinical significance.Methods Serum levels of IL-18,IL-6 and TNF-α were detected by ELISA in 48 cases with VM,and 30 normal healthy people as controls.CK-MB was also measured using an immune inhibitory method.Results Serum IL-18,IL-6,TNF-α and CK-MB levels of in VM group with the acute phase were significantly higher compared with those of VM group with recovery phase and control group（P0.01）,however there was no significant difference in the serum IL-18,IL-6,TNF-α and CK-MB levels between VM Group with the recovery phase and control group（P0.05）.There was positive correlation between IL-18,IL-6 and TNF-α and CK-MB in the patients with acute VM（P0.05）.Conclusion Overexpression of IL-18,IL-6 and TNF-α may be heavily involved in the pathogenesis of VM,and their can be indicators for assessing severity and judging prognosis.
出处
《实用心脑肺血管病杂志》
2010年第11期1563-1564,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
