85例胃癌患者血清总胆固醇及高密度脂蛋白测定的意义

Significance of blood serum cholesterol and high density lipoprotein detection in patients with stomach carcinoma: a report of 85 cases

对８５ 例胃癌病人进行血清总胆固醇（ＴＣ） 及高密度脂蛋白（ＨＤＬ－ Ｃ） 测定，并与４２ 例良性胃病和正常对照组４２例进行比较，发现胃癌病人血清ＴＣ和ＨＤＬ－ Ｃ 与良性胃病组和正常对照组差异有高度显著性（ Ｐ＜ ０ ．０１） ，同时还发现随胃癌的进展，患者的血清ＴＣ 和ＨＤＬ－ Ｃ水平呈现逐渐下降的趋势，提示胃癌病人ＴＣ及ＨＤＬ－ Ｃ 越低预后越差；认为胃癌患者ＴＣ及ＨＤＬ－ Ｃ 水平下降的可能原因是恶性肿瘤细胞对胆固醇的需要增加和癌细胞内胆固醇向ＨＤＬ

The comparison of blood serum TC and HDL-C between 85 patients with stomach carcinoma and 42 cases with benign stomach disease and normal control group (42 cases) showed that there were significantly statistical difference (P<0.01), and blood serum TC and HDL-C tended to decrease slowly with the progress of stomach carcinoma. It indicated that the lower TC and HDL-C were, the worse the prognosis was. TC and HDL-C descent in patients with stomach carcinoma may be the cause which malignant tumors needed more cholesterol and the relief of cholesterol to HDL decreased in the tumor cells.