冷冻治疗口腔恶性黑色素瘤的体会(附107例病例分析)

Evaluation of cryosurgery for the management of oral malignant mucomembranous melanoma A survey of 107 cases reports

目的初步探索冷冻外科在处理口腔恶性黑色素瘤原发灶中的作用。方法回顾分析单纯手术治疗１３例、单纯冷冻治疗２４例和综合治疗７０例口腔颌面部恶性黑色素瘤的临床资料。结果三种方法治疗后３年和５年生存率分别是０．０％、０．０％；３７．５０％、３１．２５％及５７．１４％、３６．０７％。单纯手术组与冷冻组及综合治疗组存在统计学显著差异，但后两者疗效无统计学差异。结论提示综合治疗黑色素瘤是值得提倡的治疗方案。

Objective As to study the effects of cryosurgery in the dealing with oral melanoma,a clinical survey of 107 cases was made. Methods There were 13 cases underwent operation.24 cases underwent cryosurgery only and 70 cases received comprehensive management,which as cryosurgery,operation,chemotherapy and immunotherapy. Results The 3'and 5' year survival rate of three groups were 0.0%,0.0%,37.50%,31.25% and 57.14%,36.07%.There are significant differences between operation group and cryosurgery group and between operation group and comprehensive treatment group.Although the third group got the better result,but the difference between late two groups was not statistical significant. Conclusion It is suggested that comprehensive treatment be the routine regime of melanoma in head and neck.Our experience with review of literature covered the classification,surgical principle and complication was presented.