肝硬化时血浆胃肠激素与胃肠动力障碍的关系

The relationship between serum gastrointestinal hormone and gastroenteric kinetic malfunction in human hepatic cirrhosis

目的了解肝硬化时胃肠激素与胃肠动力障碍的关系。方法对８３例肝硬化患者进行二周以上西沙比利治疗前后的血浆胃动素（ＭＴＬ）、生长抑素（ＳＳ）、血管活性肠肽（ＶＩＰ）水平测定比较，以及２０例正常人的血浆胃动素，生长抑素、血管活性肠肽的观察进行比较。结果肝硬化组ＭＴＬ、ＶＩＰ较正常组异常升高，但治疗后血浆ＭＴＬ、ＶＩＰ、ＳＳ水平较治疗前无明显变化，不与临床症状改善密切相关。结论肝硬化患者存在明显胃肠动力障碍，胃肠激素紊乱是其重要原因之一，但还有其他因素共同作用，肝功能损害程度是决定因素，西沙比利用于治疗肝硬化时消化不良症状有效，但保肝、利胆等治疗更为重要。

Aim To find out the relationship between serum gastrointestinal hormone and gastroenteric kinetic malfunction in hepatic cirrhosis. Methods Samples were divided into two groups;normal control(n=20) and hepatic cirrhosis group(n=83),serum MTL. SS and VIP were measured after the treatment with cispride for two weeks by 5mg three times per day,serum MTL,SS and VIP of all the patients were assayed ,and the comparision was made then. Results Serum MTL and VIP were higher in hepatic cirrhosis than those in normal control group.after the treatment with cispride,serum MTLVIP and SS didnot change significantly and had no close relation to the improved symptoms and signs. Conclusion Gastroenteric kinetic disorders in hepatic cirrhosis results from coexistence of many factors Compared with the damage of hepatic function,the disturbance of gastrointestianl endocrine is less important,cispride is an effective remedy for gastrointestinal kinetic malfunction,but improving hepatic function is basic and far too emergent in fact.