慢性肝炎患者载脂蛋白α_1及β_(100)水平检测的临床意义

The clinical significance of testing apo 1 and apo 100 levelsin patients with chronic hepatitis

目的评价慢性肝炎患者载脂蛋白（ａｐｏ）α１和ａｐｏβ１００的变化和临床意义。方法以３０４例慢性肝炎（ＣＨ）患者为研究对象，包括轻度５０例，中度８２例，重度２９例，重型肝炎（ＳＨ）７２例及肝炎肝化（ＬＣ）７１例。酶法检测血清ａｐｏα１和ａｐｏβ１００，以低于正常参考值下限为降低。结果ＣＨ轻、中、重度、ＳＨ及ＬＣ发生ａｐｏα１和ａｐｏβ１００下降的比例分别为２２％与１４％，４８８％与１１％，９３１％与４４８％，９７２％与４７２％，７３２％与３３８％。下降程度以ＳＨ组最显著，依次为ＣＨ重度和ＬＣ组，而ＣＨ轻度和中度组改变较小。血清ａｐｏα１与血清总胆红素水平及凝血酶原时间成明显负相关。结论血清ａｐｏα１和ａｐｏβ１００特别是ａｐｏα１水平是反映肝细胞炎症活动程度的敏感指标。

Aim To investigate the incidence and to evaluate the clinical significance of variation of apo 1 and apo 100 in patients with chronic viral hepatitis. Methods Enzymoimmunoelectrophoresis was used to assay apo 1 and apo 100 levels in 304 serum samples from various types of viral hepatitis.Other liver functions such as total bilirubin (TB) level and prothrombin time (PT) were simultaneously detected using routine methods. Results The incidences of low levels of apo 1 and apo 100 were 48.4% and 18% in CH,73.2% and 33.8% in LC and 97.2% and 47.2% in SH.The more serious the activity of hepatitis,the lower the serum level of apo 1 and apo 100.The negative relationship were found between apo 1 and TB,apo 1 and PT,apo 100 and TB,and apo 100 and PT. Conclusions Apo 1 and apo 100(especially apo 1) are sensitive indexes for diagnosis of degree of viral hepatitis.