善得定治疗急性胰腺炎临床对照分析

Controlled clinical analysis of octreotide in treatment of acute pancreatitis

目的探讨善得定治疗急性胰腺炎的临床疗效。方法将３４例急性胰腺炎患者随机分为２组，１７例用善得定每ｈｒ２５ｕｇ，另１７例不用善得定，对照临床症状改善情况及Ｒａｎｓｏｎ预后指标。结果善得定治疗组中腹痛完全消失者较多，镇痛药应用较少，且４８ｈｒ后不良预后指标较少，包括血球压积降低１０％以上和血钙＜８ｍｇ／ｄｌ的患者显著少于对照组。结论用善得定治疗急性胰腺炎可减轻症状，减少并发症，并防止病情恶化。

Aims To evaluate the clinical effect of octreotide in treatment of acute pancreatits. Methods Tirty-four patients with acute pancreatitis were randomly divided into two groups,17 patients were treated with octreotide,25ug per hour,and the other 17 patients who did not receive octreotide treatment were as control.The differences of clinical symptoms and the ranson prognostic criteria were compared between the two groups. Results More patients in the octreotide treated group relieved abdominal pain completely,and analgetics was less required in the group.After 48 hr the octreotide-treated group developed significalntly fewer poor prognostic indicators,including falls in hematocrit to >10% and in serum calcium to <8mg/dl. Conclusions Octreotide may improve the symptoms, reduce the complications,and prevent deterioration of acute pancreatitis.