胃粘膜肠化生细胞DNA含量测定与增殖状态分型的关系

The relations between the cell proliferation types and the DNA content of the cells in intestinal metaplasia of gastric mucosa

目的：探讨胃粘膜肠化生细胞ＤＮＡ含量与增殖状态分型、硫酸化粘液分泌状况之间的关系。方法：采用ＤＮＡ图像分析技术测定３９４例胃粘膜活检及外科手术标本中细胞ＤＮＡ含量，并对１８７例伴肠化生慢性萎缩性胃炎作免疫组化与粘液组化套染，进行肠化生增殖状态分型。结论：胃粘膜出现肠化生和异型增生、癌变时，出现异倍体细胞且百分率显著增高（Ｐ＜０．０１）；高增殖型肠化生中异倍体细胞的百分率显著高于中、低增殖型肠化生（Ｐ＜０．０１）。结论：提示高增殖型肠化生与胃癌的发生密切相关。

Objective: To discuss the relations among the DNA content of the cells in intestinal metaplasia of gastric mucosa,the cell proliferation types and the mucosecieting in gastric mucosa. Methods: With the DNA picture analyzing technique, the DNA contents of the cells, 394 cases of gastric mucosa and surgical samples were determined and 187 cases of CAG with intestinal metaplasia were typed proliferatiuely by immunohistochemistry and mucoushistochemistry staining methods. Results: When cancer, intestinal metaplasia and abnormal hyperplasia appeared in gastric mucosa, the percent rate of abnormal cells was significantly increased ( P <0.01) and it was higher in HPT than that in MPT or LPT ( P <001). Conclusions: HPT highly correlates to the occurrece of gasric cancer.