摘要
目的：探讨ＣｅｒｂＢ２和ｎｍ２３Ｈ１产物在结肠癌中表达的临床意义。方法：用ＬＳＡＢ法对６４例结肠癌标本的ＣｅｒｂＢ２和ｎｍ２３Ｈ１基因产物的表达进行研究。结果：ＣｅｒｂＢ２蛋白表达与组织类型及淋巴结转移有相关性（Ｐ＜０．０５）；ｎｍ２３Ｈ１表达与淋巴结转移及Ｄｕｋｅｓ分期有相关性（Ｐ＜０．０５）；在结肠癌中两基因产物表达呈正相关（ｒ＝０．４３３Ｐ＜０．０５）。结论：ＣｅｒｂＢ２和ｎｍ２３Ｈ１在结肠癌发生发展中起协同作用，同时检测两种基因产物表达可作为评判结肠癌的临床特征的重要指标。
Objective To investigate the expression of the CerbB2 and
nm23H1 gene products and their clinical significance in colon carcinoma. Methods The
expression of the CerbB2 and nm23H1 gene products in 64 cases of colon carcinoma were
analysed quantitatively by immunohistochemical LSAB method. Results The CerbB2 gene
product expression was correlated to pathological types and lymph metastasis; Expression of
nm23H1 protein was correlated with lymph metastasis and Dukes'staging. Conclusions The
expression of CerbB2 and nm23H1 gene product cooperate in growth and progression of colon
carcinoma. Both CerbB2 and nm23H1 gene products were objective clinical indicator.
