肝动脉泵内化疗治疗晚期肝癌的临床研究

Clinical study of chemotherapy through hepatic arterial vital port in advanced liver cancer

目的：观察肝动脉泵内化疗对晚期肝癌的疗效。方法：泵内予以ＦＤ和ＦＭ方案交替小剂量化疗（每周一次，６个月为一疗程）治疗１２例晚期肝癌患者。结果：ＣＲ４例，ＰＲ４例，ＮＣ２例，ＰＤ２例。有效率为６６．７％（８／１２）。３年及５年生存率分别为３３．３％和１６．７％。结论：泵内长期小剂量化疗可以提高晚期肝癌的生存率。

Objective: To observe the effect of chemotherapy through hepatic arterial pump. Methods : Twelve cases were treated by little dose combination chemotherapy of FD or FM(Alternate once a week,one course of six months) through hepatic arterial vital port. Results :CR was observed in 4 cases,PR in 4 cases,NC in 2 cases,PD in 2 cases.The overall response rate was 66.7%(8/12).Three year survival rate was 333%,five year survival rate was 167%. Conclusions :Survival rate of patients with advanced liver cancer was increased by long time little dose combination chemoheraphy through hepatic arterial vital port.