新疆昌吉市心脑血管疾病患者血清总胆汁酸与血脂分析

Analysis of the level of serum total bile acids and blood lipid in heart and cerebrovascular diseases in Changji area of Xinjian

目的探讨昌吉市回族、汉族心脑血管疾病与血清总胆汁酸的关系。方法分别测定原发性高血压组42例、冠心病组36例、脑卒中组33例和健康对照组51例受试者血清总胆汁酸(TBA)、三酰甘油(TG)、总胆固醇(TCH)、高密度胆固醇(HDL-c)、低密度胆固醇(LDL-c)的水平,并进行分析。结果原发性高血压组、冠心病组和脑卒中组患者血清TBA、TG、TCH、LDL-c水平均高于健康对照组,差异有统计学意义(P<0.05),其中原发性高血压组血清总胆汁酸含量最高。HDL-c水平低于健康对照组;所有受试者血清TBA和血脂水平的民族差异均无统计学意义。结论血清总胆汁酸的变化对心脑血管疾病的诊断、治疗和预后有重要的临床意义。

Objective To probe the clinical significance of serum total bile acids（TBA）level in heart and cerebrovascular diseases between the Muslim and Han people in Changji of Xinjiang.Methods The concentrations of serum triglycerides（TG）,total cholesterol（TCH）,high density lipoprotein-cholesterol（HDL-c）,and low density lipopro tein-cholesterol（LDL-c）were measured in 42 cases of hypertensive disease,36 cases of coronary heart disease,and 33 cases of cerebral apoplexy disease and 51 healthy control,respectively,and then the results were analyzed.Results Compared with the control group,the serum TBA,TG,TCH,and LDL-c levels in the patients with heart and cerebral vusculer diseases were significantly higher（P0.05）,with the serum TBA level in the patients with hypertension being the highest.However,the HDL-c level of those patients was lower than that of the control group,and there wasn＇t ethnic difference in the level of serum TBA and blood lipid in the tests.Conclusion The results suggest that the level of TBA might play an important clinical role in diagnosing and treating heart and cerebrovascular diseases.