扬州地区531例羊水染色体核型分析

Analysis of 531 cases of amniotic fluid karyotype in Yangzhou region

目的分析产前诊断的孕妇羊水细胞染色体核型,讨论产前诊断指标对诊断胎儿染色体的意义。方法对531例有产前诊断指征的孕妇在B超介导下行羊膜腔穿刺术,取羊水细胞培养和染色体制备,对结果进行分析。结果 B超介导下行羊膜腔穿刺术,穿刺失败2例,穿刺成功529例,培养成功的例数为521例,成功率为98.49%。染色体正常核型510例,核型异常11例,异常率为2.11%。结论羊膜腔穿刺术是一种安全,可靠的产前诊断方法,在孕中期就能鉴别异常核型,对于减少染色体异常胎儿的出生有着重要的意义。

Objective To explore the Karyotype of aminotic cell of the pregnant women who are under prenatal diagnose,and discuss whether some of the criteria of the prenatal diagnose are of importance.Methods With the help of B-ultrasound,amniocentesis were applied on 531 pregnant women who have some dangerous facts in pregnant screen,and the amniotic cells were obtained,and cultured to prepare chromosome,and then the Karyotype results were analyzed.Results In 531 amniocentesis,529 are successful and only 2 failed,with the samples of successful amniotic cell culture being 521.In the 521 samples,the normal are 510,while the abnormal are 11.Conclusion Amniocentesis is a safe and reliable operation,because we are able to identify abnormal Karyotype in this way,so it is of an important significance in reducing the fetal chromosomal abnormalities at birth.