摘要
建立用气相色谱外标法分析磺胺嘧啶中残留溶剂乙酸的方法。实验结果表明在HP—INNOWAX色谱柱上乙酸能与其他组分很好的分离，分离度（α）〉20，且乙酸峰型对称。乙酸浓度在01116-5.580mg／mL范围内，r=0．9999，呈现良好的线性关系。乙酸检测限为0．025％，定量限为0．085％。采用的样品处理方法回收率高且对色谱柱及检测器的污染小。该法操作简便、快速、准确性高、重复性好；该法的平均加标回收率为98．19％。对同一样品的精密度实验结果表明，不同实验员不同日的RSD以及不同分析仪器的RSD均小于2．0％。可作为本品的质量控制方法。
Gas chromatographic method was employed for the quantitative determination of acetic acid in sulfadiazine. Experimental results showed that a good separation of acetic acid with other contents of sample was achieved on HP-INNOWAX column, and the separation degree was more than 2.0. The linear range was 0.1116-5.580 mg/mL with r = 0.9999 and the relative standard deviation was less than 2.0 %. The method was simple, rapid, accurate and precise, and the limit of detection was 0.025 %. The averange recovery of the method was 98.19 %.
出处
《广东化工》
CAS
2010年第10期121-122,共2页
Guangdong Chemical Industry
关键词
气相色谱法
乙酸
磺胺嘧啶
gas chromatography
acetic acid
sulfadiazine
