法舒地尔治疗急性脑梗死的疗效观察

Clinical observation of fasudil hydrochloride in acute cerebral infarction

目的观察法舒地尔治疗急性脑梗死的临床疗效。方法将120例确诊为急性脑梗死患者随机分为治疗组和对照组,各60例。治疗组给予法舒地尔30mg,静脉滴注,每天2次;奥扎格雷80mg静脉滴注,每天1次。对照组单用奥扎格雷80mg,静脉滴注,每天1次。2组疗程均为2周。根据神经功能缺损程度评分标准来观察临床效果。结果治疗组总有效率为90.0%高于对照组的73.3%,差异有统计学意义(P<0.05)。2组治疗后神经功能缺失评分均低于治疗前,差异有统计学意义(P<0.01);且治疗组低于对照组,差异有统计学意义(P<0.05)。结论法舒地尔治疗急性脑梗死安全有效,值得临床推广。

Objective To evaluate the clinical effects of fasudil hydrochloride in acute cerebral infarction.Methods 120 cases patients with acute cerebral infarction were randomly divided into treatment group（n = 50） and control group（n = 50） .Treatment group were given fasudil hydrochloride（30mg once,twice a day） and ozagrel（80mg,once a day）,intravenous drips;Control group were only given ozagrel,intravenous drips,80mg,once a day;The course in both groups lasted for 2 weeks.Based on clinical nerve functional lmpairment level score standard,observed the clinical curative effect.Results The total effective rate of treatment group（90.0% ） was higher than that in control group（73.3% ）,the difference was statistically significant（P 0.05） .After treatment,neurologic deficit scores of two groups were lower than before treatment,the difference was statistically significant（P 0.01）;And lower than control group,the difference was statistically significant（P 0.05） .Conclusion Fasudil hydrochloride is effective in treating patients with acute cerebral infarction.