心房利钠肽和脑钠肽及血管紧张素Ⅱ与妊娠高血压综合征的相关性研究进展

Correlation Research Progress of Pregnancy-induced Hypertension,and Atrial Natriuretic Peptide,Brain Natriuretic Peptide and Angiotensin Ⅱ

妊娠高血压综合征是妊娠期特有的疾病,严重威胁母婴安全,是严重的妊娠并发症。当妊娠高血压综合征发生时,已造成了肾、胎盘等由功能性发展为器质性损害。妊娠高血压综合征基本的病理、生理变化是全身小动脉痉挛和水钠潴留,但其病因及发病机制仍未完全阐明。因此,探讨其发病机制有重要意义。妊娠高血压综合征患者血浆中的心房利钠肽、脑钠肽及血管紧张素Ⅱ的浓度明显高于正常孕妇,并与妊高征的严重性呈正相关。

Pregnancy induced hypertension（PIH）is specific in gestational period.It is a serious threaten to mothers and babies.When gestational hypertension occurs,it has progressed from the functional damages to the organic damages to kidneys and placentae.The elemental change is the systemic arteriospasm and water-sodium retention.Its pathogenesis is yet to investigate.It is of great significance to approach the pathogenesis of PIH.Atrial natriuretic peptide,brain natriuretic peptide and angiotensin Ⅱ are obviously increased in PIH than normal pregnant women,proportionally correlated with PIH.