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乳腺癌中DNA甲基化与ER和PR及HER-2表达的关系 被引量：2

Correlation of DNA Methylation and the Expression of Estrogen Receptor,Progesterone Receptor,Human Epidermal Growth Factor Receptor 2 in Breast Cancer
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摘要 DNA甲基化是人类基因组发生的最为常见的一种表观遗传学事件,在乳腺癌发生相关机制中具有重要意义。激素受体阳性和阴性的乳腺癌中DNA甲基化的模式和频率不同。DNA甲基化可能参与了三苯氧胺耐药的发生,也是提示预后的因素之一。研究乳腺癌相关基因异常甲基化与其雌激素受体、孕激素受体和人类表皮生长因子受体2表达的关系,有助于进一步明确乳腺癌的分子分型,指导诊断和临床预后,也有助于阐明内分泌治疗的耐药机制。 DNA mehylation is one of the most common epigenetic events in human genome,and plays important role in breast cancer etiology.The methylation profiles and frequence vary in breast cancer with different hormone receptor status.DNA methylation is involved in tamoxifen resistence,and may be one of the prognostic factors.Research on correlation between aberrant DNA methylation profiles in breast cancer related genes and expression of estrogen receptor,progesterone receptor and human epidermal growth factor 2 contributes to molecular classification,diagnosis,prognosis and mechanisms of tamoxifen resistence in breast cancer.
作者 贾楠 冯炜炜
机构地区 复旦大学附属妇产科医院
出处 《医学综述》 2010年第20期3075-3077,共3页 Medical Recapitulate
关键词 乳腺癌 DNA甲基化 雌激素受体 孕激素受体 人类表皮生长因子受体2 Breast cancer DNA methylation Estrogen receptor Progesterone receptor Human epidermal growth factor receptor 2
分类号 R737.9 [医药卫生—肿瘤] R730.231.4 [医药卫生—肿瘤]
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参考文献30

  • 1Widschwondter M,Jones PA.DNA methylation and breast carcinogenesis[J].Oncogene,2002,21 (35):5462-5482.
  • 2Esteller M.Epigenetic gone silencing in cancer:the DNA hypermethylome[J].Hum Mol Goner,2007,16 (R1):RS0-R59.
  • 3Kim MS,Lebron C,Nagpal JK,et al.Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer[J].Biochem Bioph Res Co,2008,370(1):38-43.
  • 4Brevet M,Haren N,Sevestre H,et al.DNA Methylation of KV1.3 potassium channel gone promoter is associated with poorly differentiated breast adenocarcinoma[J].Cell Physiol Biochem,2009,24 (1/2):25-32.
  • 5Paluszczak J,Krajka-Ku z niak V,Baer-Duboska W.The effect of dietary polyphenols on the epigenetic regulation of gone expression in MCF7 breast cancer cslls[J].Toxicol Lett,2010,192(2):119-125.
  • 6Fabianowska-Majewska K,Kordek R,Krawczyk B.Studies on the methylation status of CpG sequences located in promoters of selected tumor suppressor genes in breast cancer cells[J].Nucleos Nucleot Nucl,2006,25(9/11):1025-1028.
  • 7Mirza S,Sharma G,Plasad CP,et al.Promoter hypermethylation of TMS1,BRCA1,ERα and PRB in serum and tumor DNA of invasire ductal breast carcinoma patiants[J].Life Sci,2007,81 (4):280-287.
  • 8Jing F,Jun L,Yong Z,et al.Multigene methylation in serarn of sporadic Chinese female breast cancer patients as a prognostic biomarker[J].Oncolegy,2008,75 (1/2):60-66.
  • 9Feng WW,Shen LL,Wen SJ,et al.Correlation between CpG methylation profiles and hormone receptor status in breast cancers[J].Breast Cancer Res,2007,9 (4):R.57.
  • 10Tao MH,Shields PG,Nie J,et al.DNA hypermethylation and clinicepatholegical features in breast cancer:the Western New York Exposures and Breast Cancer (WEB) Study[J].Breast Cancer Ros Treat,2009,114 (3):559-568.

同被引文献36

  • 1李美蓉,范松青,张利群,蒋谊.乳腺癌激素受体和癌基因的表达及临床意义[J].中国医师杂志,2006,8(1):34-37. 被引量：5
  • 2封敏,黄艳春,赵锋.乳腺癌组织中C-erbB-2基因蛋白的表达及其意义[J].新疆医科大学学报,2006,29(10):976-978. 被引量：2
  • 3Cherubini M, Baxa P, Guarino G. The oestrogen-progesterone receptor ratio: an indicator of breast cancer evolution[ J ]. Chir Ital, 2002, 54(4) : 423-428.
  • 4Riou G, Mathieu MC, Barrois M, et al. C-erbB-2(HER-2/neu) gene amplification is a better indicator of poor prognosis than protein over-expression in operable breast-cancer patients [ J ]. Int J Cancer, 2001, 95(4) : 266-270.
  • 5Wolff AC, Hammond ME, Schwartz JN, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendation for human epidermal growth factor 2 testing in breast cancer[J]. Arch Pathol Lab Med, 2007, 131 ( 1 ) : 18-43.
  • 6Mylonas I, Makovitzky J, Jeschke U, et al. Expression of HER2/neu, steroid receptors( ER and PR) , Ki67 and P53 in invasive mammary ductal carcinoma associated with ductal carcinoma in situ (DCIS) versus invasive breast cancer alone [J]. Anticancer Res, 2005, 25(3A) : 1719-1723.
  • 7Beenken SW, Grizzle WE, Crowe DR, et al. Molecular biomarkers for breast cancer prognosis : coexpression of C-erbB-2 and P53[J]. Ann Surg, 2001,233(5) : 630-638.
  • 8Perou CM, Sφrlie T, Eisen MB, et al. Molecular portraits of human breast tumors[J]. Nature, 2000, 406(6797) : 747-752.
  • 9Sorlie T,Wang Y,Xiao Ctet al. Distinct molecular mechanisms underly-ing clinically relevant subtypes of breast cancer: gene expression analysesacross three different platforms"〕. BMC Genomics,2006;26(7) :127.
  • 10Hanmann 0,Spyratos F,Harbeck N,ei al. DNA methylation maricers pre-dict outcome in node-positive, estrogen receptor-positive breast cancerwith adjuvant anthracycline-based chemotherapy [ J]. Clin Cancer Res,2009;15(1) :315-23.

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医学综述
2010年 第20期

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