1Esteller M,Herman JG.Generating mutations but providing chemosensitivity:the role of O6-methylguanine DNA methyltransferase in human cancer[J].Oncogene,2004,23(1):1-8.
2Middleton MR,Margison GP.Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway[J].Lancet Oncol,2003,4(1):37-44.
3Esteller M,Garcia-Foncillas J,Andion E,et al.Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents[J].N Engl J Med,2000,343(19):1350-1354.
5Cahill DP,Levine KK,Betensky RA,et al.Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment[J].Clin Cancer Res,2007,13(7):2038-2045.
7Sarkaria JN,Kitange GJ,James CD,et al.Mechanisms of chemoresistance to alkylating agents in malignant glioma[J].Clin Cancer Res,2008,14(10):2900-2908.
8Hermisson M,Klumpp A,Wick W,et al.O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells[J].J Neurochem,2006,96(3):766-776.
9Frese KK,Tuveson DA.Maximizing mouse cancer models[J].Nat Rev Cancer,2007,7(9):645-658.
10Carver BS,Pandolfi PP.Mouse modeling in oncologic preclinical and translational research[J].Clin Cancer Res,2006,12(18):5305-5311.
2Sabharwal A, Middleton MR. Exploiting the role of O^6-methylguanine DNA methyltransferase (MGMT) in cancer therapy [J]. Curr Opin Pharmacol, 2006,6(4) :355-363.
3Gerson SL. MGMT: its role in cancer aetiology and cancer therapeutics [ J ]. Nat Rev Cancer, 2004,4(4) : 296-307.
4Jaeinto FV, Esteller M. MGMT hypermethylation: a prognostic foe, a predictive friend [J]. DNA Rep, 2007,6(8) : 1155-1160.
5Helleday T, Petermann E, Lundin C, et al. DNA repair pathways as targets for cancer therapy [J]. Nat Rev, 2008,8 ( 3 ) : 193 -204.
6Lee S, Kim WH, Jung HY, et al. Aberrant CpG island methylation of multiple genes in intrahepatie cholangiocarcinoma [J]. Am J Pathol, 2002,161(3) : 1015-1022.
7Hegi ME, Diserens A-C, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma [J]. N Engl J Med, 2005,352(10) : 997-1003.
8Gal-Yam EN, Saito Y, Egger G, et al. Cancer epigenetics: modifications, screening, and therapy [J]. Annu Rev Med, 2008,59 : 267-280.
9Leung WK, To KF, Chu ES, et al. Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer [J]. Br J Cancer, 2005, 92(12) : 2190-2194.
10Usadel H, Brabender J, Danenberg KD, et al. Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer [ J ]. Cancer Res, 2002,62 (2) : 371-375.