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恶性脑胶质瘤烷化剂耐药机制及其调节 被引量:1

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摘要 烷化剂是用于治疗恶性脑肿瘤的主要药物,通过破坏DNA并诱导细胞凋亡对肿瘤细胞进行杀伤作用。内在性或获得性的烷化剂耐药是恶性脑肿瘤患者治疗失败的主要原因。烷化剂治疗脑肿瘤受多种途径调节影响:包括DNA修复途径、碱基切除修复(BER)途径等,对其影响途径的研究有助于克服烷化剂耐药,同时采用临床前模型试验有助于制订有效治疗方案克服耐药及促进药物开发。
作者 沈峰 于朝春
出处 《徐州医学院学报》 CAS 2010年第10期697-700,共4页 Acta Academiae Medicinae Xuzhou
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