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不同宫颈病变组织HPV6/11、HPV16/18、p53、Ki67表达的临床意义 被引量：4

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摘要 目的 探讨人乳头状病毒（HPV）6/11、HPV 16/18、p53、Ki67表达与宫颈病变的关系及临床意义.方法 应用原位杂交及免疫组化技术,检测150例不同宫颈病变患者宫颈组织的HPV 6/11、HPV 16/18、p53、Ki67表达.结果 在宫颈良性病变、恶性病变及正常对照组织中,4个检测指标比较均有统计学差异（P均＜0.05）;在宫颈尖锐湿疣、炎症病变、宫颈上皮内瘤变Ⅰ～Ⅱ中,HPV 6/11、p53、Ki67表达阳性率比较均有统计学差异（P＜0.01或＜0.05）;p53表达在正常组织与良性病变中有统计学差异（P＜0.05）;HPV 16/18在良、恶性病变中有统计学差异（P＜0.01）.结论 在正常宫颈组织向恶性病变发展中,HPV 16/18、Ki67表达逐渐增强,p53表达逐渐降低;HPV 6/11在宫颈尖锐湿疣病变中高表达,在宫颈正常组织、恶性病变中表达较低.对宫颈活检时行HPV 6/11、HPV 16/18、p53、Ki67检测,有助于宫颈恶性病变的早期诊断.
作者 范丽萍 丁宇 李静 徐彤 邱俊勇
机构地区 韶关粤北人民医院
出处 《山东医药》 CAS 北大核心 2010年第37期81-82,共2页 Shandong Medical Journal
关键词 宫颈病变 HPV 6/11 HPV 16/18 p53 KI67
分类号 R711.74 [医药卫生—妇产科学]
  • 相关文献

参考文献7

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二级参考文献22

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共引文献61

同被引文献37

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引证文献4

二级引证文献28

山东医药
2010年 第37期

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