成都地区婴幼儿喘息性疾病的病毒血清学研究

Study on viral serology of wheezing illnesses in young children in Chengdu area.

目的了解近年成都地区婴幼儿喘息性疾病病毒感染的病原学情况。方法采用酶联免疫吸附法(ELISA)对2007年7月～2009年6月本院内科的1200例1个月～3岁婴幼儿喘息性疾病患儿进行呼吸道合胞病毒(RSV)、腺病毒(AdV)、流感病毒(IFV)、副流感病毒(PIV)的IgM抗体测定,并对年龄、性别、季节和不同疾病的感染情况进行分析。结果 1200例患儿中有243例病毒检测阳性,阳性率20.25%。其与疾病、季节、年龄的关系见表1～3。结论病毒依然是成都地区婴幼儿喘息性疾病主要病原,<1岁婴儿病毒感染率较高,好发于冬春季节。以毛细支气管炎的检出率最高(24.7%),主要病原为RSV。临床上应重视婴幼儿喘息性疾病的病毒病原学研究。

Objective To investigate the prevalence of viral infection as an etiological factor for wheezing illnesses in young children in Chengdu area over recent years.Methods Children aged 0～3years suffered from wheezing illnesses in young children,who were admitted to the Chengdu Children′s Hospital from July 2007 to June 2009 were chosen.Enzyme-linked immunosorbent assay（ELISA） technique was used to determine serum IgM level against RSV、AdV、IFV and PIV.Simultaneously the possible influencing factors such as age,gender,season and different disease,then analyze the results.Results Among all the 1200 samples,243（20.25%）positive results were determined,those influencing factors were shown in table 1～3.Conclusion Viral was discovered to be high in the young children with wheezing illnesses in Chengdu area.The infection rate was relatively high among infants below one-year old of age.was also simultaneously epidemic in winter and spring.Of the 243,the positive results of bronchiolitis was highest（24.7%）,RSV.was the first infection pathogen of bronchiolitis.More attention should be paid to viral enology of wheezing illnesses in young children.