期刊文献+

原发性干燥综合征患者T细胞亚群及CD4^+CD25^+ T细胞检测的意义 被引量:6

The significance of T lymphocyte subsets and CD4^+CD25^+ T cells detection in patients with primary Sjogren's syndrome
下载PDF
导出
摘要 目的探讨T淋巴细胞亚群及CD4+CD25+T细胞在原发性干燥综合征(PSS)患者中的检测意义。方法用流式细胞仪检测18例PSS患者以及20例健康体检者外周血CD3+、CD3+CD4+、CD3+CD8+、NK细胞(CD3-/CD16+56+)、CD3+CD4-CD8-双阴性T细胞及CD4+CD25+调节T细胞水平。结果 PSS患者与正常对照组比较,CD3+CD4+细胞亚群的百分率明显升高(P<0.05);CD4+/CD8+与对照组比较有明显升高(P<0.05);CD3+CD4-CD8-双阴性T细胞及CD4+CD25+调节性T细胞的百分率明显降低(P<0.01),其它T细胞亚群无明显变化。结论 PSS患者T淋巴细胞亚群的水平是异常的。T细胞亚群的比例异常与疾病的病程和临床表现相关联。CD3+CD4-CD8-和CD4+CD25+调节性T细胞水平降低导致机体自身免疫反应抑制功能减弱,免疫耐受状态被打破,可能是引发PSS发生发展的重要因素。 Objective To investigate the significance of T lymphocyte subsets and CD4+CD25+ T cells detection in patients with primary Sjogren syndrome(PSS).Methods A flow cytometry was use to detect the levels of peripheral blood CD3+,CD3+CD4+,CD3+CD8+,CD3-/CD16+56+ of NK cells,double negative T cells of CD3+CD4-CD8-and CD4+CD25+ which regulate the levels of T cells in 18 patients with PSS,and compared with 20 healthy subjects(as normal control group).Results Compared with normal control group,the percentage of PSS patients' CD3+CD4+cell subsets were significantly elevated(P0.05);CD4+/CD8+ was also significantly higher(P0.05); double negative T cells of CD3+CD4-CD8-and CD4+CD25+ which regulate the levels of T cells decreased significantly(P0.01),other T cell subsets remained the same.Conclusion The levels of T lymphocyte subsets in patients with PSS is abnormal.The proportion of T cell subsets abnormalities was associated with the course and clinical manifestations of the disease.The decreased CD3+CD4-CD8-and CD4+CD25+ which regulate the levels of T cells resulted in weakening self immune suppression,and immune tolerance has been broken,they may be important factors which induced the genesis and development of PSS.
出处 《右江民族医学院学报》 2010年第5期665-667,共3页 Journal of Youjiang Medical University for Nationalities
关键词 干燥综合征 T淋巴细胞 CD4+CD25+ CD3+CD4-CD8- Sjogren's syndrome T cell subsets CD4+CD25+ CD3+CD4-CD8
  • 相关文献

参考文献7

二级参考文献19

  • 1厉小梅,李向培,钱龙,汪国生,张红,翟志敏,李庆,陈柯,王小秋,王怡平.CD_4^+ CD_(25)^+调节性T细胞在干燥综合征患者外周血和唇腺组织的表达[J].中华医学杂志,2007,87(15):1034-1036. 被引量:9
  • 2[1]Jacobsson LTH,Axell TE,Hansen BU,et al.Dry eyes and mouth:an epidemiological study in Sweden adult,with special reference to primary Sj gren's syndrome[J].J Autoimmun,1989,2:521.
  • 3[2]Tsubota K,Hirai S,King LS,et al.Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjgren's syndrome[J].Lancet,2001,357(9257):688-689.
  • 4[3]Hulkkonen J,Pertovaara M,Kantonen J,et al.Genetic association between interleukin-10 promoter region polymorphisms and primary sjogren's syndrome[J].Arthritis Rheum,2001,44(1):176-179.
  • 5[4]Witte T,Matthias T,Arnett FC,et al.IgA and IgG autoantibodies against α-Fodrin as markers for SS[J].J Rheumatol,2000,27(11):2617-2620.
  • 6[6]Zhu Z,Stevenson D,Schechter JE,et al.Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis[J].Invest Ophthalmol Vis Sci,2004,45(5):1375-1381.
  • 7[7]Koski H,Janin A,Humphreys-Beher MG,et al.Tumor necrosis factor-alpha and receptors for it in labial salivary glands in Sjogren's syndrome[J].Clin Exp Rheumatol,2001,19(2):131-137.
  • 8[8]Pijpe J,Imhoff GW,Spijkervet FK,et al.Rituximab treatment in patients with primary Sjogren's syndrome:an open-label phase Ⅱ study[J].Arthritis Rheum,2005,52(9):2740-2750.
  • 9[9]Epratuzumab Steinfeld SD,Tant L,Burmester GR,et al.(humanised anti-CD22 antibody) in primary Sjogren's syndrome:an open-label phase Ⅰ/Ⅱ study[J].Arthritis Res Ther,2006,8(4):129.
  • 10[10]Mariette X,Ravaud P,Steinfeld S,et al.Inefficacy of infliximab in primary Sjogren's syndrome:results of the randomized,controlled Trial of Remicade in Primary Sjogren's Syndrome (TRIPSS)[J].Arthritis Rheum,2004,50(4):1270-1276.

共引文献37

同被引文献62

引证文献6

二级引证文献41

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部