双亲水含糖梳形共聚物的合成

Synthesis of Double-Hydrophilic Comb Copolymers Containing Glycopolymer Segments

用Williamson反应合成了端基为苯乙烯的聚氧乙烯(PEO)大分子单体,通过PEO大分子单体和引发剂型单体N-(4-(2-溴代异丁酰氧基)苯基)马来酰亚胺(BiBPMI)的共聚合成了原子转移自由基聚合(ATRP)引发单元和PEO侧链均匀分布的梳形共聚物。用该聚合物作为大分子引发剂,引发糖单体6-O-甲基丙烯酰基-1,2;3,4-双-O-亚异丙基-α-D-吡喃半乳糖(MAIPGal)在室温下的ATRP。用核磁共振(1H-NMR)和凝胶渗透色谱(GPC)对聚合物进行了表征,证明利用苯乙烯和马来酰亚胺的共聚特性,合成得到了PEO侧链和含糖侧链均匀分布的梳形共聚物,脱保护后得到双亲水共聚物。

Comb copolymers were obtained by the copolymerization of an inimer,N-（4-（2-bromoisobutyryloxyl）phenyl）maleimide （BiBPMI）,with a styryl poly（ethylene oxide （PEO） macromonomer,which was synthesized by the Williamson reaction. The comb polymer was used as the macroinitiator of atom transfer radical polymerization （ATRP） of a sugar monomer,6-O-methacryloyl-1,2;3,4-di-O-isopropylidene-D-galactopyranose （MAIPGal）. The resulted comb copolymer was characterized by 1H-nuclear magnetic resonance spectrum（1H-NMR） and gel permeation in chromatography（GPC）. It is demonstrated to have a well-defined distribution of PEO and glycopolymer side chains due to alternating copolymerization tendency of styryl and maleimide groups. A double-hydrophilic comb copolymer containing glycopolymer segments can be obtained after deprotection of the isopropylidene groups.