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p16与HR-HPV载量在宫颈上皮内瘤样病变相关性 被引量：1

Correlation of p16 expression and viral load of high risk human papillomavirus with cervical intraepithelial neoplasia
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摘要 目的研究p16蛋白与高危型人乳头状瘤病毒(HR-HPV)载量在轻度宫颈上皮内瘤样病变(CIN1)中的关系,以指导诊治CIN。方法选择阴道镜活检CIN1组织,进行p16蛋白免疫组化标记,用第二代杂交捕获法(HC-Ⅱ)检测HR-HPV载量,分析p16表达与HR-HPV载量相关性。结果 75例中,p16阳性表达率60.0%;不同p16表达程度组的HR-HPV载量不同(P<0.05),表达阴性与弱阳性组间有统计学差异(P<0.05);p16表达强度和病毒载量成正相关(P<0.05)。结论在CIN1中,p16蛋白表达与HR-HPV病毒载量相关,高表达与高HR-HPV病毒载量一致。 Aim To investigate the correlation of protein p16 expression and viral load of high-risk human papillomavirus （HR-HPV） with low-grade cervical intraepithelial neoplasia （CIN1）. Methods Immunocytochemical analysis of protein p16 in 75 CIN1 biopsy tissues was performed and viral load of HR-HPV was detected by hybrid capture Ⅱ（ HC-Ⅱ）. Results The positive rate of p16 expression was 60.0% and the expression level of p16 was positively correlated with HR-HPV load ,showing significant difference（P〈 0.05）. Conclusion The overexprssion of protein p16 is correlated with high load of HR-HPV in CIN1.
作者 蒋春萍 刘少燕 徐洪
机构地区 蛇口人民医院
出处 《中国热带医学》 CAS 2010年第12期1505-1507,共3页 China Tropical Medicine
基金 深圳市南山区科技研发资助项目基金资助(基金编号2009023)
关键词 P16蛋白 人乳头状瘤病毒 病毒载量 杂交捕获 宫颈上皮内瘤样病变 Protein p16 Human Papillomavirus Viral Load Hybrid capture Cervical Intraepithelial Neoplasia
分类号 R711.32 [医药卫生—妇产科学]
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参考文献11

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二级参考文献23

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中国热带医学
2010年 第12期

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