登革疫苗研究进展

Research progress on dengue vaccine

随着登革病毒的传播,登革热已经成为热带及亚热带地区重要的,快速增长的公共卫生问题。登革热和严重的登革出血热、登革休克综合症已威胁到全球25亿人的健康。目前,迫切需要一种安全、有效的登革疫苗。然而,基于接种疫苗可能使个体在登革病毒感染时易于发展成严重登革热的担心放缓了登革疫苗的发展。人们已经研发了一系列的候选登革疫苗,包括减毒活疫苗,灭活疫苗,嵌合疫苗,亚单位疫苗,DNA疫苗,核酸疫苗。其中一些正处于临床试验阶段。本文仅就登革疫苗的研究进展作一综述。

The spread of dengue virus throughout the tropics and subtropics represents a major,rapidly growing public health problem with an estimated 2.5 billion people at risk of dengue fever and the life-threatening disease,severe dengue：dengue hemorrhagic fever and dengue shock syndrome. A safe and effective vaccine for dengue is urgently needed. Vaccine development has been slowed by fears that immunisation might predispose individuals to the severe form of dengue infection. A pipeline of candidate vaccines now exists,including live attenuated,inactivated,chimeric,subunit,DNA,and viral-vector vaccines,some of which are at the stage of clinical testing. In this Review,we present the progress that is being made in the development of a vaccine.